NODDI, which stands for Neurite Orientation Dispersion and Density Imaging, is a technique used in diffusion MRI to assess the microstructure of brain tissue. It provides more specific markers of brain tissue microstructure than standard diffusion tensor imaging (DTI). NODDI models the diffusion signal as the contribution of three compartments: intracellular, extracellular, and cerebrospinal fluid. This allows researchers to estimate parameters like neurite density and orientation dispersion, offering insights into the complexity of neurites (axons and dendrites) in the brain. Source: Google Search